Bioactive Small Molecules
Cayman Chemical OH-Chol, Purity: ≥95%, CAS: 191173-82-7, 5 mg
A cationic cholesterol derivative; has been used in lipoplexes with DOPE for siRNA delivery and gene silencing in MCF-7 cells as well as in mice via intravenous injection, resulting in lipoplex accumulation in the liver; has been used in cationic nanoparticles in combination with Tween 80 to transfect pDNA and siRNA into PC3 mouse xenografts via intratumoral injection; has been used in cationic nanoparticles in combination with Tween 80 and folate-PEG2000-DSPE in a KB mouse xenograft model for intratumoral gene delivery
Medchemexpress LLC SIRP gamma Cynomolg 5ug | 5ug
SIRP gamma Protein a member of signal-regulatory protein (SIRP) family is the only SIRP detected on T cells and activated NK cells SIRP gamma can bind CD47 providing T cells and NK cells with a cell surface molecule capable of interacting with CD47 SIRP gamma-CD47 interaction mediates strong cell-cell adhesion and supports T cell-APC contact enhancing antigen presentation and consequent T-cell proliferation and cytokine secretion SIRP gamma Protein Cynomolgus (HEK293 His) is the recombinant cynomolgus-derived SIRP gamma protein expressed by HEK293 with C-His labeled tag
Medchemexpress LLC Adenylyl cyclase type 2 agonist-1 | 2414908-52-2 | MFCD01346226 | 99.3% | 550.78 g/mol | C27H17BrClNO5 | 5 MG
Adenylyl cyclase type 2 agonist-1 is a small-molecule research compound provided as a light yellow solid with reported purity of 99.3% and a molecular weight of 550.78 g/mol. It functions as an adenylyl cyclase type 2 agonist for laboratory research and should be stored protected from light under recommended temperature conditions.
- High purity suitable for research applications.
- Light yellow to yellow solid for easy visual identification.
- Molecular weight 550.78 g/mol supports formulation calculations.
- Chemical formula C27H17BrClNO5 for substance identification.
- Storage recommendations: 4°C, protect from light; in solvent: -80°C (6 months), -20°C (1 month).
Cayman Chemical Naphthol AS-E Phosphate, Purity: ≥98%, CAS: 18228-17-6, 5 mg
An inhibitor of the protein-protein interaction between CREB and KIX domains; disrupts binding between CREB and the KIX domain of CBP (Ki = 50 µM); inhibits binding of Myb to the KIX domains of p300 and CBP (IC50s = 30 and 43 µM, respectively); inhibits CREB-dependent transcription in HEK293T cells (Ki = 10 µM); decreases the expression of Myb target genes and induces differentiation in HL-60, U937, and NB4 myeloid leukemia cells at 5 µM; inhibits proliferation of NCI-H1734 lung adenocarcinoma cells (IC50 = 6.89 µM)
Medchemexpress LLC Basigin/CD147 Mouse 10ug
The Basigin/CD147 protein is essential for retinal maturation and development acting as a NXNL1 receptor to promote the survival of retinal cone photoreceptor cells Basigin/CD147 Protein Mouse (304a a HEK293 His) is the recombinant mouse-derived Basigin/CD147 protein expressed by HEK293 with C-6 His labeled tag
Cayman Chemical 2-Fluoroethcathinone (hydrochloride), Purity: ≥98%, CAS: 2446466-63-1, 5 mg
A fluorine-substituted synthetic cathinone that has potential for abuse; intended for forensic and research applications
Selleck Chemical LLC BD750 S0981-5MG
BD750 is an immunosuppressant and a dual inhibitor of JAK3 and STAT5 that inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation with IC50 of 1 5 M and 1 1 M for mouse and human T-cell proliferation respectively
Medchemexpress LLC MEL24 | 642072-48-8 | C17H18N4O3 | 25 MG
MEL24 is an Mdm2 E3 ligase inhibitor that reduces cell survival and increases sensitivity to DNA damaging agents in a p53-dependent manner for in vitro antitumor studies.
- Reduces cell survival
- Increases sensitivity to DNA damaging agents
- Suitable for in vitro antitumor studies
- Acts on 293T cells with an ED50 value of 9.2 μM
- Increases levels of Mdm2, p53, and MdmX
- Activates p53
- Inhibits the degradation of endogenous MdmX in HCT116 cells
Enzo Life Sciences Ac-LEVD-AFC (1mg)
Caspase-4 substrate. Fluorogenic substrate for caspase-4. Similar to the fluorogenic substrate Ac-LEVD-AMC (ALX-260-083); the AFC fluorophore is more sensitive. Alternative name: Caspase 4 substrate (fluorogenic). Formula: C32H40F3N5O11. MW: 727.7. Purity: ≥98% (HPLC). Peptide content: 75-95%. Solubility: Soluble in DMSO; dilute with distilled water or buffer; also soluble in phosphate buffer, pH 7.5-8.0. Long Term Storage: -20°C. Use/Stability: Dissolve only as much as needed at one time because of the possibility of decomposition in solution. Store solution at -20°C. Protect from condensation: when taking the sample out of the container, wait until it warms up to room temperature, then open it. Handling: Keep cool and dry.
Medchemexpress LLC Adenosylhomocysteinase (SAHH; AHCY) | 9025-54-1 | ≥140 U/mg protein | 44 kDa | 5 MG
Adenosylhomocysteinase (SAHH; AHCY) is a highly conserved enzyme that reversibly catalyzes S-adenosylhomocysteine (SAH) to adenosine and L-homocysteine. It has a molecular weight of 44 kDa, is stable in the pH range of 6.0-8.0, and is intended for research use only.
- Reversibly catalyzes S-adenosylhomocysteine (SAH) to adenosine and L-homocysteine
- Serum exosomal level acts as a prognostic biomarker in HBV-LC patients
- Obtained by microbial recombination
- Stable in pH range of 6.0-8.0
- Reconstitute with pure water containing 20% glycerol
- Store at 4°C for up to one year after reconstitution
- For extended storage, aliquot and freeze at -20°C; avoid repeated freeze-thaw cycles
Apexbio Technology LLC NPPB 107254-86-4 50mg
NPPB (5-nitro-2-(3-phenylpropylamino)-benzoic acid CAS 107254-86-4) is a small molecule inhibitor of chloride ion channels It acts via interaction sites that include a negatively charged carboxyl group a secondary amine and a nitro substituent contributing partial negative charge facilitating polar interactions with aromatic residues NPPB inhibits chloride currents with reported IC50 values of 80 nM for short-circuit current assays In rat portal vein cells NPPB reduces calcium-activated chloride currents by 58 96% and suppresses up to 90% of norepinephrine- and acetylcholine-induced BK(Ca) potassium currents It also inhibits volume-activated taurine influx (IC50 12 M) NPPB is utilized in studies dissecting chloride and potassium channel function and volume-regulated organic solute transport
Cayman Chemical MEGA-9, Purity: ≥95%, CAS: 85261-19-4, 5 g
A nonionic detergent that can be used to solubilize membrane proteins; CMC = 20 mM under no-salt conditions; CMCs = 2-17.1 mM under high and low salt conditions for a variety of salts; has been used to solubilize the melibiose transport carrier from E. coli membranes and reconstitute it into liposomes
Cayman Chemical Gedunin, Purity: ≥98%, CAS: 2753-30-2, 1 mg
A natural inhibitor of p23 chaperone function; inhibits Hsp90 expression in vitro in NTERA-2 cells at 5 µg/ml; binds to and blocks p23 to induce apoptosis in HeLa-PRB cells (20 µM); inhibits breast cancer cell proliferation in vitro (IC50s = 8.84 and 3.22 µM in MCF-7 and SKBr-3 cells, respectively); inhibits PANC-1 pancreatic cancer cell growth in vitro (IC50 = 25 µM); has anti-inflammatory effects in mouse models of articular inflammation when used at doses of 0.05–0.5 mg/kg and allergic inflammation when used at a dose of 0.5 mg/kg; targets LPS binding and TLR4 signaling in macrophages when used at a concentration of 10 µM
Medchemexpress LLC 1-propanesulfonamide derivative (PROTAC BRAF-V600E degrader-1) | 2417296-84-3 | 98.0% | C48H54F2N10O10S | 10MG
PROTAC BRAF-V600E degrader-1 is a research-grade targeted protein degrader that selectively induces proteasomal degradation of the oncogenic BRAF-V600E mutant. It shows low-nanomolar affinity for BRAF variants and is intended for cellular and biochemical research applications.
- Selective degradation of BRAF-V600E via the ubiquitin-proteasome system.
- Low-nanomolar binding affinity to BRAF and BRAF-V600E for potent activity.
- High purity suitable for cellular assays and biochemical studies.
- Available in small-mass sizes convenient for research workflows.
- Provided for research use only; not for clinical applications.
![Medchemexpress LLC 7-(2-hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carb | 1231889-53-4 | MFCD30470964 | 99.1% | 502.56 | C31H26N4O3 | 2 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000245266.png-250.jpg)
Medchemexpress LLC 7-(2-hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carb | 1231889-53-4 | MFCD30470964 | 99.1% | 502.56 | C31H26N4O3 | 2 MG
BMS-935177 is a small-molecule, reversible inhibitor of Bruton's tyrosine kinase (BTK) developed for research use. It is described in the medicinal chemistry literature as a potent and selective BTK inhibitor with an IC50 of approximately 3 nM and is supplied as a solid with high reported purity for biochemical and cellular studies.
- Potent reversible inhibitor of Bruton's tyrosine kinase (IC50 ≈ 3 nM).
- High selectivity for the BTK target in kinase panels.
- Molecular formula C31H26N4O3 and molecular weight 502.56.
- Supplied as a solid with reported purity around 99.1%.
- Available in small pack sizes suitable for research (for example, 2 MG solid).
- Soluble in DMSO and commonly provided as a 10 mM solution for assays.
- Store powder at low temperature for long-term stability (e.g., -20°C).